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We Tested the Best Stain Removers for Clothes, and These 7 Will Easily Lift Dirty Imperfections

Including the best solution to tackle emergency messes

Shout Advanced Grease Busting Foam, Laundry Stain Remover on a table next to folded laundry and washing machine in background

The Spruce / Henry Wortock

While you may have luck getting a stain or two out of your favorite blouse with one cycle in the wash and an effective laundry detergent, some stains are tougher than others and may require a pre-treatment with a laundry stain remover.

Most stain removers for clothes use enzymes or oxidation, which break down and remove tough stains from your favorite garments, upholstery, carpet, and more. But which are the best laundry stain removers? We’re glad you asked. We tested 37 stain-fighters in The Lab to help you find the best solution for your precious stained items. 

We tested the removers on common, hard-to-lift stains, including red wine, chocolate, ink markings, and mustard. We then continued to evaluate their ease of use, cleaning effectiveness, and scent.

Whether you’re known for spilling your beverage while on the go or just want an effective cleaner on hand to lift your kiddo’s food spills and outdoor stains, we’ve included stain removers for just about every lifestyle.

Hand spraying Shout Advanced Grease Busting Foam, Laundry Stain Remover on a t-shirt with stain
PHOTO: The Spruce / Henry Wortock
What We Like
  • Effectively removes various stain types

  • Designed to remove grease and oil

  • Unscented formula

What We Don't Like
  • Quick-acting formula can’t dry on garment before laundering

  • Not ideal for wine and foundation stains

After rigorously testing 37 laundry stain removers, Shout Advanced Grease Busting Foam earned a spot as our best overall pick for its high stain-removing performance, ease of use, and practical price point of just $4. 

This foaming spray is formulated to remove tricky oil and grease stains from food and auto care. We love how simple it is to use this spray. After we saturated our stains in the foam, we tossed it in the wash, and voila, you’re done. Just be sure not to leave this cleaning agent to dry on your stained garments before laundering, as it won’t be the most effective.

We also love that the spray is unscented. So if you’re someone who dislikes the strong, chemical fumes that most cleaning products have, you’ll love Shout’s Advanced Grease Busting Foam

Type: Spray foam | Amount: 18 ounces | Scent: No noticeable scent | Application Method: Spray and launder before drying

Person spilling wine on a T-shirt next to a bottle of Shout Advanced Ultra Concentrated Gel Stain Remover

The Spruce / Henry Wortock

Typical Ingredients in Stain Removers

Formulas vary from brand to brand. But here are a few standout ingredients: Oxygen-based cleaners share a similar bubbly reaction as hydrogen peroxide to lift out stains and dirt. Then, there’s enzymatic cleaners, such as protease (to target protein stains) and amylase (to treat starch-based stains). Enzyme cleaners use enzymes and microbes to break down organic stains. These bio-powered cleaners can be used to remove laundry stains, carpet stains, and pet messes.

What We Like
  • Effectively removes red wine and grass stains

  • Can be used as a pre-treatment or as an add-on in the wash

  • Works great on various surfaces

What We Don’t Like
  • Cleaning application is labor intensive

For those whose whites may need a little brightening and sparkle, the OxiClean Versatile Stain Remover Powder is the perfect laundry care solution.

This oxygen-based bleach cleaner also removes hard-to-lift green grass streaks that seem almost impossible to remove from clothing effectively. Our editor, in fact, uses OxiClean regularly to tackle especially difficult stains, like dark food spills that have been sitting, as well as pen marks and makeup messes.

What Our Tester Said

"The OxiClean Versatile Stain Remover seemed very effective. Not many products will remove makeup or red wine," our tester says. "The red wine was completely removed."

Similar to powder detergent, this stain remover comes in a container that’s filled with three pounds of loose powder and includes a plastic measuring cup to customize your pour. However, this cleaner can be used on various surfaces outside of laundry, such as the kitchen, bathroom, furniture, and more, but the application is a bit more tedious. 

Using an empty spray bottle, you can mix the OxiClean powder with water to create a multi-surface cleaning solution. We found that mixing the concoction can be a little messy, though. 

But the process is way simpler if you’re purchasing this stain remover powder strictly for clothing. You can add the powder straight to your load of laundry along with your desired detergent or even pre-soak your clothing before laundering (which we found to be most effective for especially tough stains). 

Type: Powder | Amount: 48 ounces | Scent: No noticeable scent | Application Method: Mix with water and apply, or pre-soak

A person holds up a box of Amodex Liquid Ink & Stain Remover
PHOTO: The Spruce / Henry Wortock
What We Like
  • Ideal for active households with kids

  • Effectively lifts chocolate and ink stains

  • No noticeable scent before or after washing

What We Don’t Like
  • Could benefit from a spray bottle for ease of use

  • Less effective on old, set-in stains

Whether you have a sensitive nose or hate the harsh smell that most cleaning products leave behind, opting for an unscented cleaner may be ideal. With no noticeable scent before or after the wash, the Amodex Liquid Ink & Stain Remover is our winning pick.

During testing, this ink and stain remover erased the chocolate, butter, and ink pen markings the best, whereas the mustard and wine stains faded but were still clearly visible.

What Our Tester Said

"Of the two stain removers I tested, this product performed better," our tester says. "I believe this is a good stain remover, but you would need to treat the stain right away and give it some time to soak in and do its work."

This stain remover comes in a small, four-ounce squeeze bottle. While we believe that the cleaner would be much easier to use in a spray bottle, we love being able to drop the solution directly onto the stain, which also prevents product waste.

Type: Liquid | Amount: 4 ounces | Scent: No scent detected | Application Method: Apply a few drops, rub in with fingers, and wash

What We Like
  • Portable and slim enough to fit in a purse or desk

  • No washing required

  • Bleach-free formula can be used on various fabrics

What We Don’t Like
  • Not ideal for larger size stains

There’s always that one person who has a Tide Stain Remover Pen on hand, and those who don’t are always super appreciative of prepared friends whenever an accidental spill happens while we’re out. 

These compact, bleach-free pens effectively erase just about any stain on all fabric types. We found that Tide pens work best on grass, syrup, and ink marker stains. While the wine stain was significantly lightened, it still needed more treatment. 

What Our Tester Said

"Definitely a product to keep on hand, though the small size and slow application process makes this more of an emergency product, or better suited for smaller areas," says our tester.

I’m personally notorious for spilling sauce on my top whenever I’m out dining, so I can also vouch for this stain remover. Two hours post-brunch, I noticed a blob of dried syrup on my black sweater, which I was able to immediately lift, thanks to a friend, who had a Tide To Go Instant Stain Remover in her purse. There was no need to change outfits or run home to a washing machine. 

While this pen is great for emergency spills while on-the-go, it doesn’t replace a traditional wash, and because of its small size and slow application process, removing larger-sized stains is not suggested.

Type: Pen | Amount: 3 pens | Scent: Light chemical smell | Application Method: Blot stain, press pen tip, rub gently

What We Like
  • Quick, on-the-spot cleaning

  • Ideal for parents with frequent kid spills

  • Portable and travel friendly

  • Doubles as a shoe cleaner

What We Don't Like
  • Small 4-ounce size

If you prefer a quick-acting cleaner that'll lift your textile's filthiest stain within a few spritzes, consider Miss Mouth's Messy Eater Treater Spray. After testing the popular cleaner ourselves, we can see this being every parent's go-to stain remover and a diaper bag necessity.

This spray can be used on various stained fabrics and surfaces, including linen, upholstery, suede, and your kiddo's toys. Its biodegradable formula can also double as shoe clean and carpet stain remover.

What Our Editor Said

"I love that I watch stains disappear after spraying them with this treatment. Even persistent stains are washed out in the laundry. I can totally see how the small size of the bottle would be an awesome essential in a diaper bag, too." - Emma Phelps, editor at The Spruce

While we love how portable Miss Mouth's Messy Eater Treater Spray is, this may not be the longest-lasting cleaner given its small, 4-ounce size. Given the small amount of product you get, we also think this spray can be quite costly. For longevity purposes, we would use this spray on small stains or while on the go.

Carbona Laundry Stain Scrubber on a white table with washing machine in background
PHOTO: The Spruce / Henry Wortock
What We Like
  • Constructed with a scrubber brush head

  • Works great on set-in stains

  • Subtle scent

What We Don't Like
  • Brush applicator tends to smear fresh stains

If your favorite shirt has a dried, set-in stain, don’t worry, it can still be saved. The Carbona Laundry Stain Scrubber is a Spruce-approved, standout pick, thanks to its unique scrubbing brush head and stain-removing formula that lifts tough, set-in spills.

Unlike any cleaner on our list, this Carbona stain remover is constructed with a built-in brush applicator. The brush made us feel like we were actually working the treatment into our dried stains. That is, until it came time to test the fresh stains.

During testing, the applicator picked up the fresh chocolate, but unfortunately smeared it onto the next stain. From our testing, we highly recommend sticking to old, set-in stains when using this stain fighter.

If you prefer your cleaning products to have a subtle and underwhelming scent, the Carbona Laundry Stain Scrubber will be right up your alley. We put our noses directly up to the applicator to detect the cleaner's scent and were delighted with its light yet pleasant smell.

Type: Gel | Amount: 8.4 ounces | Scent: Light | Application Method: Apply from bottle, use scrubber to work in stain

What We Like
  • Long saturation time of up to 24 hours

  • Plant-based formula

  • Spray nozzle application targets stains with ease

What We Don't Like
  • All stains weren’t equally removed

For busy households filled with little ones whose clothes are always covered with fresh food spills, we highly recommend keeping a bottle of Seventh Generation’s Laundry Stain Remover on hand. 

While the product didn’t effectively eliminate all the stains equally, we noted that the cleaner performed better on newer, fresh stains than dried, set-in ones.

If you’re someone with a busy schedule and can’t get to the laundry room right away, you can quickly pre-treat your stain with a few spritzes of this remover and won’t have to worry about throwing it in the wash for up to 24 hours.

And if you’re someone who prides themselves on using eco-friendly products, you’ll love the Seventh Generation Laundry Stain Remover even more. This cleaner has a plant-based formula with no dyes or fragrances. Plus, you can’t beat the price point of $4. 

Type: Spray | Amount: 16 ounces | Scent: Unscented | Application Method: Spray, wash within 24 hours

Final Verdict

For our best overall pick, we love Shout’s Advanced Grease Busting Foam, which is simple to use and formulated to remove tricky oil and grease stains. We were impressed that it can pretty much tackle just about any stain you throw at it. If you have a sensitive nose, our best unscented pick is the Amodex Liquid Ink & Stain Remover, which easily removes chocolate, butter, and ink pen markings.

a pen, stick of butter, hershey's bar, bottle of wine, and mustard bottle on a white t-shirt next to their respective stains on the shirt

The Spruce / Henry Wortock

How We Tested the Laundry Stain Removers

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Testing Laundry Stain Remover for Effectiveness and Ease of Use

We tested 37 laundry stain removers in the last two years. Narrowing our list down to just six standout picks came with a lot of analysis and comparisons, especially relating to its ease of use, stain-fighting performance, and scent. 

We made sure to select stain removers that represent each household’s lifestyle, including green cleaners that prefer gentle ingredient products and those who are always on-the-go and need something portable.

We also know there are those who are prone to spills and need a cleaner that’s powerful enough to lift tough set-in stains. To make sure we were thorough in our testing, we purposely dirtied up t-shirts with common household stains, such as mustard, wine, chocolate, greasy butter, and ink, to see which laundry stain removers were most effective.

Hands on a laptop next to a pile of clothes with stains on them

The Spruce / Henry Wortock

What to Look for in a Laundry Stain Remover

Choose Your Application Method

There are several application categories to choose from; we found a favorite in each one. For example, if you prefer a simple spray like Shout Advanced Grease Busting Foam, our best overall pick, which can be applied straight on the stain, or a portable pen like Tide To Go Instant Stain Remover, our best on-the-go pick, that’s great for minor spills. 

There’s also a soak option that won’t require you to use any elbow grease. This method is found in our best powdered pick, the OxiClean Versatile Stain Remover. We love that you can add the powder straight to your load in the wash or pre-treat it with a water mixture.

Hand using a Tide To Go Instant Stain Remover on a stained T-shirt

The Spruce / Henry Wortock

Consider Effectiveness on a Range of Stains

The good news is that most stain removers are going to lift the dirt and stains on your wardrobe. However, some are better at erasing certain types of stains than others, whether that's last night's wine or dried, set-in stains of turkey gravy, or fresh ones from today's chocolate bar you just munched on at lunch. 

You can also find a stain remover like our best overall, the Shout Advanced Grease Busting Foam, specifically formulated for oil and grease stains, but we think it's really a jack of all trades, removing every stain type out there.

Hand places yellow clothing into a washing machine

The Spruce / Henry Wortock

Choose a Suitable Product Depending on Fabric Type

When shopping for the best laundry stain remover, you’ll want to pick one that's suitable for various fabrics, as you’ll most likely experience food and bio-based stains on a number of outfits, such as your pretty silk blouse, your wool sweater, or your favorite cotton t-shirt. This will boil down to the ingredient list. For example, the Tide To Go Instant Stain Remover (our best on-the-go pick) is made with a bleach-free formula, so you can use it on a variety of materials and colors.

A person sprays Charlie's Soap Biodegradable Laundry Pre-Spray Stain Remover on a stain

The Spruce / Henry Wortock

Follow Your Nose: Unscented vs. Scented

The stain remover’s scent may be minor, but it’s often a worthwhile buying consideration that will help you make your final decision. While most of the cleaners on our list are unscented, if you’re a fragrance person, consider our best option for tough stains, the Carbona Laundry Stain Scrubber, which has a light and pleasant scent.

If you’re not a scent person or you have sensitivities, we suggest considering an unscented laundry stain remover. Most of the picks in our guide are scentless, but our favorite has to be the Amodex Liquid Ink & Stain Remover. Plus, it's the best chocolate stain remover and also erases stubborn pen and marker streaks, so it's a win-win!

Why Trust The Spruce?

This article was written by Kenedee Fowler, a Spruce shopping writer who specializes in everything home related, including the best laundry care, cleaning products, and bath linens. Fowler has had her fair share trying to scrub out sauce spills from her favorite garments. She's also known for dropping her food and coffee spills on her shirts!

For this guide, Fowler referenced two years' worth of testing insights. She also compared each cleaner's product descriptions, unique features, ingredient lists, and application methods to narrow our list from 37 to eight.